期刊
JOURNAL OF THORACIC ONCOLOGY
卷 16, 期 4, 页码 619-629出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jtho.2020.12.005
关键词
Tumor spread through air spaces (STAS); Lung adenocarcinoma; Frozen section; Reproducibility; Diagnostic yield
This study evaluated the accuracy and consistency of STAS detection in early-stage lung adenocarcinomas on frozen section, finding that FS had low sensitivity and high specificity for detecting STAS, indicating a need for more precise criteria.
Introduction: Tumor spread through air spaces (STAS) is associated with worse prognosis in early-stage lung adenocarcinomas, particularly in sublobar resection. Intraoperative consultation for STAS has been advocated to guide surgical management. However, data on accuracy and reproducibility of intra-operative assessment of STAS remain limited. We evaluated diagnostic yield, interobserver agreement (IOA), and intraobserver agreement (ITA) for STAS detection on frozen section (FS). Methods: A panel of three pathologists evaluated stage 1 lung adenocarcinomas (n = 100) for the presence or absence of STAS and artifacts as reference. Five pulmonary pathologists independently reviewed all cases in two rounds, detecting STAS and artifacts in FS and the corresponding FS permanent and non-FS permanent, with a consensus conference between rounds. Results: The FS had low sensitivity (44%), high specificity (91%), relatively high accuracy (71%), and overall area under the receiver operating characteristic curve of 0.67 for detecting STAS. The average ITA was moderate for both STAS (kappa(mean): 0.598) and artifact (kappa(mean): 0.402) detection on FS. IOA was moderate for STAS (kappa(round-1): 0.453; kappa(round-2): 0.506) and fair for artifact (kappa(round-1): 0.300; kappa(round-2): 0.204) detection on FS. IOA for STAS improved in FS permanent and non-FS permanent, whereas ITA was similar across section types. On multivariable logistic regression, the only significant predictor of diagnostic discordance was the presence of artifacts. Conclusions: FS is highly specific but not sensitive for STAS detection in stage 1 lung adenocarcinomas. IOA on STAS is moderate in FS and improved only marginally after a consensus conference, raising concerns regarding global implementation of intraoperative assessment of STAS and warranting more precise criteria for STAS and artifacts. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
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