期刊
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
卷 18, 期 6, 页码 1433-1442出版社
SPRINGER
DOI: 10.1007/s13738-020-02127-2
关键词
Magnetic carbon nanocomposites; Magnetic-dispersive solid-phase extraction; Ion pair-dispersive liquid– liquid; Sulfonamide residues; High-performance liquid chromatography
资金
- research council of Razi University of Kermanshah (Iran)
- Iranian Research, and Development Center for Chemical Industries, Tehran, Iran (ACECR)
In this study, a magnetic-dispersive solid-phase extraction coupled with ion pair-dispersive liquid-liquid micro-extraction (MSPE-i-DLLME) method was developed for the pre-concentration and extraction of sulfonamides residues in animal foodstuffs. The optimized extraction parameters resulted in high pre-concentration factors and sensitivity, making the method successfully applicable for the determination of sulfonamides residues in animal foodstuffs.
In this study, magnetic-dispersive solid-phase extraction coupled with ion pair-dispersive liquid-liquid micro-extraction (MSPE-i-DLLME) was used to the pre-concentration and extraction of five sulfonamides residues (sulfadiazine, sulfathiazole, sulfacetamide, sulfamethazine and sulfamethoxazole) in animal foodstuffs. The sulfonamides are extracted using magnetic carbon nanocomposite and then eluted with acetonitrile. In the DLLME step, the target analytes are collected in 1-octanol containing 10% Aliquat-336 (as extraction solvent). Finally, the compounds are quantified by HPLC with DAD detection. The extraction parameters optimized using the one at the time and central composite design methods. Under the optimized conditions: sample solution volume was 100 mL; initial pH: 12, amounts of MCNs: 30 mg; desorption solvent (ACN) volume, 1 mL; desorption condition, 10 min sonication at two step; extraction solvent (1-octanol + 10% aliquat) volume, 115 mu L; pH of DLLME step, 3; salt effect, 24.6%, (w/v) NaCl; centrifuge, 5 min, 4000 rpm. In these extraction conditions, the proposed procedure represented good pre-concentration factors between 130 and 490; detection limits in the range from 0.01 to 5 mu g kg(-1) (at S/N = 3), and linear response in the 0.1-400 mu g kg(-1) concentration range. The method is successfully applied to the determination of sulfonamides residues in animal foodstuffs.
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