4.7 Article

Cardiovascular Aging and Longevity JACC State-of-the-Art Review

期刊

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2020.11.023

关键词

aging; cardiovascular disease; longevity

向作者/读者索取更多资源

Cardiovascular aging and longevity are interconnected through various pathophysiological mechanisms, with factors like cardiometabolic disorders and genetic modulators playing significant roles. Understanding the genetic, molecular, and biochemical pathways of aging may lead to interventions that delay cardiovascular aging, potentially contributing to achieving longevity goals. Research on long-living populations helps translate these mechanisms into clinical data for further study.
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dystipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goat of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations. (C) 2021 by the American College of Cardiology Foundation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据