期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 52, 页码 21645-21650出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c11535
关键词
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资金
- Chugai Pharmaceuticals
- Tamaki Foundation
A novel palladium-mediated carbonylogous 1,4-dipole was developed by in situ deprotonation. By using our own-developed C2-unsymmetric phosphoramidite as supporting ligand, this dipole was applied to the asymmetric synthesis of chiral cyclohexanones via a catalytic [4+2] cycloaddition. Electron-deficient allylic carbonate was used to generate the highly reactive palladium-mediated dipoles for the first time, and a diverse array of stable dipole precursors was explored for the elaboration of chiral cyclohexanones. A general mechanism for the reaction process and stereochemical outcome was proposed, which can be useful in designing and predicting future transformation.
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