期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 49, 页码 20536-20541出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c09753
关键词
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资金
- National Institutes of Health National Cancer Institute [R01 CA68682, R01 CA135274, R15 CA232765]
- Robert A. Welch Foundation [F-0018]
Immunogenic cell death (ICD) is a way of reengaging the tumor-specific immune system. ICD can be induced by treatment with chemotherapeutics. However, only a limited number of drugs and other treatment modalities have been shown to elicit the biomarker responses characteristic of ICD and to provide an anticancer benefit in vivo. Here, we report a rationally designed redox-active Au(I) bis-N-heterocyclic carbene that induces ICD both in vitro and in vivo. This work benefits from a synthetic pathway that allows for the facile preparation of asymmetric redox-active Au(I) bis-N-heterocyclic carbenes.
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