期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 49, 页码 20577-20582出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c10700
关键词
-
资金
- Emmy-Noether of the DFG [GU 1134/3]
- Heisenberg program of the DFG [GU 1134/4]
Reversing the polarity in molecules is a versatile tool for expanding the boundaries of structural space. Despite a manifold of different umpolung methods available today, overcoming the inherent reactivity still remains a constant challenge in organic chemistry. The oxidative alpha-functionalization of ketones by external nucleophiles constitute such an example. Herein, we present a hypervalent F-iodane mediated umpolung of pyridyl ketones triggered by Lewis base/Lewis acid noncovalent interactions. A wide variety of external nucleophiles are introduced with high regioselectivity applying this substrate-directing concept.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据