期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 50, 页码 20924-20929出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c09596
关键词
-
资金
- National Natural Science Foundation of China [21625204, 21790332, 21532003, 21971119]
- 111 project of the Ministry of Education of China [B06005]
- Key-Area Research and Development Program of Guangdong Province [2020B010188001]
We have developed a protocol for insertion of alkylidene carbenes into the B-H bonds of amine-borane adducts, enabling, for the first time, the construction of C(sp(2))-B bonds by means of carbene-insertion reactions. Various acyclic and cyclic alkenyl borane-amine adducts were prepared from readily accessible starting materials in good to high yields and were subsequently subjected to a diverse array of functional group transformations. The unprecedented spiro B-N heterocycles prepared in this study have potential utility as building blocks for the synthesis of pharmaceuticals. Preliminary mechanistic studies suggest that insertion of the alkylidene carbenes into the B-H bonds of the amine-borane adducts proceeds via a concerted process involving a three-membered-ring transition state.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据