期刊
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
卷 30, 期 4, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105639
关键词
COVID-19; SARS-CoV-2; Epidemiology; Ischemic stroke; Stroke mortality; Stroke; Morbidity
The study revealed that the total number of strokes decreased in the US and CA during the COVID-19 pandemic, but increased in SHS. CA demonstrated higher stroke mortality, while the US saw worse stroke morbidity and loss of independence during the pandemic. The research suggests methods to address the impact of COVID-19 on clinical stroke practice, including testing all stroke inpatients for SARS-CoV-2 and using anti-inflammatory drugs on positive patients.
Introduction: To examine the impact of the COVID-19 pandemic on stroke, the number of stroke patients, time since last known well (LKW), morbidity, and mortality of stroke patients in Southwest Healthcare System (SHS), California (CA) and the United States (US) were analyzed during 2019 and compared to 2020. Our hypothesis is that there are regional differences in stroke outcome depending on location during the COVID-19 study period which influences stroke epidemiology and clinical stroke practice. Methods: The American Heart Association's 'Get with the Guidelines' (GWTG) database was used to evaluate the following categories: code stroke, diagnosis of stroke upon discharge, inpatient mortality, modified Rankin Score (mRS) upon discharge (morbidity), and time since last known well (LKW). Stroke registry data from February through June 2019 and 2020 were collected for retrospective review. Results: The total number of strokes decreased in the US and CA, but increased in SHS during the COVID-19 study period. The US and SHS demonstrated no change in stroke mortality, but CA demonstrated a higher stroke mortality during the COVID-19 pandemic. There was greater loss of independence with increased stroke morbidity in the US during the COVID-19 pandemic. There was a significant increase in time since LKW in the US and SHS, and an increase trend in time since LKW in CA during the COVID-19 study period. Discussion: To understand the impact of the COVID-19 pandemic on stroke epidemiology, we propose that all stroke inpatients should receive a SARS-CoV-2 detection test and this result be entered into the GWTG database. We demonstrate that the regional distribution of stroke mortality in the US changed during the COVID-19 study period, with increased stroke mortality in CA. Stroke morbidity throughout the US was signifi-cantly worse during the COVID-19 pandemic. We propose methods to address the impact of the COVID-19 pandemic on clinical stroke practice such as the use of mobile stroke units, clinical trials using anti-inflammation drugs on SARS-CoV-2 positive stroke patients, and COVID stroke rehabilitation centers. (c) 2021 Elsevier Inc. All rights reserved.
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