期刊
JOURNAL OF RHEUMATOLOGY
卷 48, 期 9, 页码 1422-1426出版社
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.201283
关键词
gastroesophageal reflux disease; gastrointestinal tract; outcome assessment; scleroderma; scintigraphy; systemic sclerosis
类别
资金
- National Institutes of Health (NIH) [AR063120]
The study demonstrated that SSc patients with impaired esophageal transit scintigraphy findings have higher GIT 2.0 reflux scores, while esophageal emptying activity is negatively correlated with reflux scores.
Objective. The University of California Los Angeles Scleroderma Clinical Trials Consortium Gastrointestinal Tract 2.0 (GIT 2.0) instrument is a self-report tool measuring gastrointestinal (GI) quality of life in patients with systemic sclerosis (SSc). Scarce data are available on the correlation between patient-reported GI symptoms and motility dysfunction as assessed by esophageal transit scintigraphy (ETS). Methods. We evaluated the GIT 2.0 reflux scale in patients with SSc admitted to our clinic and undergoing ETS, and correlated their findings. Results. Thirty-one patients with SSc undergoing ETS were included. Twenty-seven were female, and 9 had diffuse cutaneous SSc. Twenty-six of 31 (84%) patients had a delayed transit and an abnormal esophageal emptying activity (EA); they also had a higher GIT 2.0 reflux score (P = 0.04). Mean EA percentage was higher in patients with none to mild GIT 2.0 reflux score (81.1 [SD 11.5]) than in those with moderate (55.7 [SD 17.8], P = 0.003) and severe to very severe scores (55.8 [SD 19.7], P = 0.002). The percentage of esoph-ageal EA negatively correlated with the GIT 2.0 reflux score (r = -0.68, P < 0.0001), but it did not correlate with the other GIT 2.0 scales and the total GIT 2.0 score. Conclusion. SSc patients with impaired ETS findings have a higher GIT 2.0 reflux score. The GIT 2.0 is a complementary tool for objective measurement of esophageal involvement that can be easily administered in day-to-day clinical assessment.
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