期刊
JOURNAL OF PHYSICS D-APPLIED PHYSICS
卷 54, 期 18, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1361-6463/abdff2
关键词
lung cancer; cold atmospheric plasma; anticancer activities
资金
- Leading Foreign Research Institute Recruitment program [NRF-2016K1A4A3914113]
- Basic Science Research Program of the National Research Foundation (NRF) of Korea
- Kwangwoon University
Oral administration of plasma-treated water (PTW) has shown efficacy in curing advanced non-small cell lung cancer (NSCLC) without toxicities observed in mice. PTW exhibits favorable anticancer effects on chemo-resistant lung cancer, similar to gefitinib, by inhibiting proliferation and angiogenesis, and enhancing apoptosis in cancer cells. Additionally, PTW contributes to an enhanced immune response and improved cachexia in the model.
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with 85% of all lung cancer reported as NSCLC. Moreover, there are no effective treatments in advanced NSCLC. This study shows for the first time that oral administration of plasma-treated water (PTW) can cure advanced NSCLC. The cold plasma in water generates a cocktail of reactive species, and oral administration of this cocktail to mice showed no toxicities even at the highest dose of PTW, after a single dose and repeated doses for 28 d in mice. In vivo studies reveal that PTW showed favorable anticancer effects on chemo-resistant lung cancer, similarly to gefitinib treatment as a reference drug in a chemo-resistant NSCLC model. The anticancer activities of PTW seem to be involved in inhibiting proliferation and angiogenesis and enhancing apoptosis in the cancer cells. Interestingly, the PTW contributes to enhanced immune response and improved cachexia in the model.
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