期刊
DIGESTIVE DISEASES AND SCIENCES
卷 61, 期 10, 页码 2963-2971出版社
SPRINGER
DOI: 10.1007/s10620-016-4249-4
关键词
Air pollution; Particulate matter; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis
资金
- Dr. Falk Pharma
- European Commission (DG-SANCO)
- International Agency for Research on Cancer (IARC)
- Danish Cancer Society (Denmark)
- Ligue contre le Cancer
- Institut Gustave Roussy
- Mutuelle Generale de l'Education Nationale
- French Institute of Health and Medical Research (INSERM) (France)
- Dutch Ministry of Health, Welfare and Sports
- Dutch Prevention Funds
- LK Research Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (the Netherlands)
- Cancer Research UK [C8221/A19170]
- Medical Research Council (UK) [MR/M012190/1]
- European Community [211250]
- Cancer Research UK [16491] Funding Source: researchfish
Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). We investigated the association between air pollution exposure and IBD. The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn's disease (CD) (n = 38) and ulcerative colitis (UC) (n = 104) and controls (n = 568) from Denmark, France, the Netherlands, and the UK, matched for center, gender, age, and date of recruitment. Air pollution data were obtained from the European Study of Cohorts for Air Pollution Effects. Residential exposure was assessed with land-use regression models for particulate matter with diameters of < 10 mu m (PM10), < 2.5 mu m (PM2.5), and between 2.5 and 10 mu m (PMcoarse), soot (PM2.5 absorbance), nitrogen oxides, and two traffic indicators. Conditional logistic regression analyses were performed to calculate odds ratios (ORs) with 95 % confidence intervals (CIs). Although air pollution was not significantly associated with CD or UC separately, the associations were mostly similar. Individuals with IBD were less likely to have higher exposure levels of PM2.5 and PM10, with ORs of 0.24 (95 % CI 0.07-0.81) per 5 mu g/m(3) and 0.25 (95 % CI 0.08-0.78) per 10 mu g/m(3), respectively. There was an inverse but nonsignificant association for PMcoarse. A higher nearby traffic load was positively associated with IBD [OR 1.60 (95 % CI 1.04-2.46) per 4,000,000 motor vehicles x m per day]. Other air pollutants were positively but not significantly associated with IBD. Exposure to air pollution was not found to be consistently associated with IBD.
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