期刊
JOURNAL OF PERIODONTAL RESEARCH
卷 56, 期 4, 页码 617-632出版社
WILEY
DOI: 10.1111/jre.12847
关键词
distributions; functions; glycosaminoglycans; mechanics; periodontium; proteoglycans
资金
- National Natural Science Foundation of China [81700929, 81671024, 81870803]
Proteoglycans are glycosylated proteins with various roles in periodontal tissue development, wound repair, immune response, and pathological processes. Study on the roles and expression patterns of proteoglycans in the periodontium can provide insight for treatments of periodontitis and gingival overgrowth. Further research and validation through genetically modified animal experiments are needed for a better understanding of periodontal proteoglycans.
Proteoglycans (PGs) are largely glycosylated proteins, consisting of a linkage sugar, core proteins, and glycosaminoglycans (GAGs). To date, more than 40 kinds of PGs have been identified, and they can be classified as intracellular, cell surface, pericellular, and extracellular PGs according to cellular locations. To illustrate, extracellular PGs are known for regulating the homeostasis of the extracellular matrix; cell-surface PGs play a role in mediating cell adhesion and binding various growth factors. In the field of periodontology, PGs are implicated in cellular proliferation, migration, adhesion, contractility, and anoikis, thereby exerting a profound influence on periodontal tissue development, wound repair, the immune response, biomechanics, and pathological process. Additionally, the expression patterns of some PGs are dynamic and cell-specific. Therefore, determining the roles and spatial-temporal expression patterns of PGs in the periodontium could shed light on treatments for wound healing, tissue regeneration, periodontitis, and gingival overgrowth. In this review, close attention is paid to the distributions, functions, and potential applications of periodontal PGs. Related genetically modified animal experiments and involved signal transduction cascades are summarized for improved understanding of periodontal PGs. To date, however, there is a large amount of speculation on this topic that requires rigorous experiments for validation.
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