期刊
JOURNAL OF PERINATOLOGY
卷 41, 期 5, 页码 928-939出版社
SPRINGERNATURE
DOI: 10.1038/s41372-020-00871-0
关键词
-
Maternal obesity may increase children's susceptibility to neurodevelopmental and neuropsychiatric disorders. Key mechanisms such as inflammation, alterations to the microbiome, epigenetic modifications, and impaired signaling pathways have been identified. Proposed interventions and future research priorities include addressing these mechanisms and knowledge gaps.
There is growing clinical and experimental evidence to suggest that maternal obesity increases children's susceptibility to neurodevelopmental and neuropsychiatric disorders. Given the worldwide obesity epidemic, it is crucial that we acquire a thorough understanding of the available evidence, identify gaps in knowledge, and develop an agenda for intervention. This review synthesizes human and animal studies investigating the association between maternal obesity and offspring brain health. It also highlights key mechanisms underlying these effects, including maternal and fetal inflammation, alterations to the microbiome, epigenetic modifications of neurotrophic genes, and impaired dopaminergic and serotonergic signaling. Lastly, this review highlights several proposed interventions and priorities for future investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据