4.5 Article

Synthesis of N -heterocyclic carbene-Pd(II)-5-phenyloxazole complexes and initial studies of their catalytic activity toward the Buchwald-Hartwig amination of aryl chlorides

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JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 940, 期 -, 页码 -

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ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2021.121683

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N-heterocyclic carbene; Palladium complex; Buchwald-Hartwig amination; Amines; Aryl chlorides

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Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand were successfully synthesized in moderate to good yields. One of the complexes showed efficient catalytic activity in the Buchwald-Hartwig amination reaction, providing an alternative catalyst for the coupling of challenging yet cost-low aryl chlorides.
Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand have been obtained in moderate to good yields by a one-pot reaction of the corresponding imidazolium salts, palladium chloride and 5-phenyloxazole under mild conditions. Initial studies showed that one of the complexes is an efficient catalyst for the Buchwald-Hartwig amination of aryl chlorides with various secondary and primary amines under the varied catalyst loading of 0.01-0.05 mol%, thus it will enrich the chemistry of NHCs and give an alternative catalyst for the coupling of challenging while cost-low aryl chlorides. (c) 2021 Elsevier B.V. All rights reserved.

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