期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 3, 页码 2254-2263出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02407
关键词
-
资金
- Shandong Provincial Natural Science Foundation [ZR2019MB045]
A manganese-catalyzed N-alkylation reaction has been demonstrated, providing access to diverse secondary amines in moderate-to-high yields. The catalytic system is practical, scalable, and suitable for synthesizing heterocycles with potential activity against Alzheimer's disease.
A manganese-catalyzed N-alkylation reaction of amines with alcohols via hydrogen autotransfer strategy has been demonstrated. The developed practical catalytic system including an inexpensive, nontoxic, commercially available MnCl2 or MnBr(CO) s as the metal salt and triphenylphosphine as a ligand provides access to diverse aromatic, heteroaromatic, and aliphatic secondary amines in moderate-to-high yields. In addition, this operationally simple protocol is scalable to the gram level and suitable for synthesizing heterocycles such as indole and resveratrol-derived amines known to be active for Alzheimer's disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据