4.7 Article

Scissoring Enaminone C=C Double Bond by Free Radical Process for the Synthesis of α-Trifluoromethyl Ketones with CF3SO2Na

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 1, 页码 1231-1237

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02431

关键词

-

资金

  1. National Natural Science Foundation of China [21861019, 21562025]
  2. Natural Science Foundation of Jiangxi Province [20202ACBL203006]

向作者/读者索取更多资源

A new method for the synthesis of α-trifluoromethyl ketones has been developed by cleaving the C=C double bond on tertiary enaminones to form a new C-CF3 bond, with the promotion of TBHP and ambient heating. Control experiments show that the reactions proceed via a featured free radical process, and deuterium labeling experiments indicate the involvement of water in product formation by providing hydrogen atoms.
The C=C double bond cleavage on tertiary enaminones, enabling the formation of a new C-CF3 bond, has been realized as a practical method for the synthesis of alpha-trifluoromethyl ketones with only the promotion of TBHP and ambient heating. Control experiments support that the reactions proceed via a featured free radical process. The deuterium labeling experiment employing D2O indicates that water participated in the product formation by donating the hydrogen atom for the newly generated alpha-C-H bond in the product.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据