期刊
JOURNAL OF ORAL PATHOLOGY & MEDICINE
卷 50, 期 7, 页码 632-638出版社
WILEY
DOI: 10.1111/jop.13140
关键词
copy number alteration; DNA ploidy; loss of heterozygosity (LOH); oral dysplasia; oral potentially malignant disorder
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
Oral leukoplakia is the most common oral potentially malignant disorder globally, with a prevalence of 2%-3% and an uncertain malignant transformation rate. DNA ploidy status and loss of heterozygosity signatures have been shown to be good predictive markers of malignant transformation besides oral dysplasia grading. However, effective markers to predict which lesions will progress to invasive carcinoma remain unclear.
Oral leukoplakia (OL) is the most common oral potentially malignant disorder, with a global prevalence of 2%-3%, variable malignant transformation rate and incompletely understood aetiology. Considering the subjectivity in oral dysplasia grading, other evaluation methods have been tested as predictors of malignant transformation. DNA ploidy status and loss of heterozygosity signatures have been shown to be good predictive markers of malignant transformation. However, effective markers to predict which lesions will progress to invasive carcinoma and by which mechanisms remain unclear. Recent evidence suggests that dysplasia progression to carcinoma occurs through neutral clonal evolution (i.e. randomly). We focus on the genetic basis of OL, encompassing the gross chromosomal alterations and single-gene mutations, and discuss such alterations in the context of aetiology, clinical presentation and progression. The deeper we understand the genetic basis of OL, the more we approach a better comprehension of the complex and poorly understood process of oral carcinogenesis.
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