期刊
JOURNAL OF NEUROSCIENCE
卷 41, 期 5, 页码 823-833出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1660-20.2020
关键词
glia; phagocytosis; neuronal pruning; model organisms
资金
- National Institute of Health [T32T32AG066574, R01 NS114222, R01MH119349]
- Glenn Foundation for Medical Research
- Simons Foundation/SFARI [488574]
- Anderson Foundation
- Marco J. Heidner Foundation Pilot Fund
- National Institutes of Health [R21 NS107771, R01-EY026215, R01 NS117934, R01 NS072212]
- Ken and Ginger Harrison Term Professor Award
- Sigma-Xi
- Pew Charitable Trusts
- Burroughs Welcome Fund
- National Institutes of Health-T32: Training in Molecular Neurodegeneration
- University of Virginia Brain Institute
- AFAR Junior Faculty Grant
The phagocytic activity of glial cells is crucial for proper nervous system development, maintenance, and health, with remarkably conserved pathways governing this engulfment process across different species and cell types.
Phagocytic activity of glial cells is essential for proper nervous system sculpting, maintenance of circuitry, and long-term brain health. Glial engulfment of apoptotic cells and superfluous connections ensures that neuronal connections are appropriately refined, while clearance of damaged projections and neurotoxic proteins in the mature brain protects against inflammatory insults. Comparative work across species and cell types in recent years highlights the striking conservation of pathways that govern glial engulfment. Many signaling cascades used during developmental pruning are re-employed in the mature brain to fine tune synaptic architecture and even clear neuronal debris following traumatic events. Moreover, the neuronglia signaling events required to trigger and perform phagocytic responses are impressively conserved between invertebrates and vertebrates. This review offers a compare-and-contrast portrayal of recent findings that underscore the value of investigating glial engulfment mechanisms in a wide range of species and contexts.
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