期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 349, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2020.577406
关键词
Brain derived neurotrophic factor; Microglia; Inflammatory pain; Neuropathic pain; Molecular biomarkers
The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain transmission both in peripheral and central nervous system (CNS). Despite evidence of a pro-nociceptive role of BDNF, recent studies have reported contrasting results, including anti-nociceptive and anti-inflammatory activities. Moreover, BDNF polymorphisms can interfere with BDNF role in pain perception. In Val66Met carriers, the Met allele may have a dual role, with anti-nociceptive actions in normal condition and pro-nociceptive effects during chronic pain. In order to elucidate the main effects of BDNF in nociception, we reviewed the main characteristics of this neurotrophin, focusing on its involvement in pain.
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