期刊
DIGESTIVE AND LIVER DISEASE
卷 48, 期 7, 页码 745-752出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2016.03.024
关键词
Chemokine; Cytokine; Duodenal mucosa; Tissue transglutaminase
资金
- IRCCS San Matteo Hospital, Pavia, Italy
Background: Immune mechanisms have been implicated in nonceliac gluten sensitivity (NCGS), a condition characterized by intestinal and/or extraintestinal symptoms caused by the ingestion of gluten in non-celiac/non-wheat allergic individuals. Aims: We investigated innate and adaptive immunity in self-reported NCGS versus celiac disease (CD). Methods: In the supernatants of ex vivo-cultured duodenal biopsies from 14 self-reported NCGS patients, 9 untreated and 10 treated CD patients, and 12 controls we detected innate cytokines - interleukin (IL)-15, tumor necrosis factor-alpha, IL-1 beta, IL-6, IL-12p70, IL-23, IL-27, IL-32 alpha, thymic stromal lymphopoietin (TSLP), IFN-alpha-, adaptive cytokines - interferon (IFN)-gamma, IL-17A, IL-4, IL-5, IL-10, IL-13-, chemokines - IL-8, CCL1, CCL2, CCL3, CCL4, CCL5, CXCL1, CXCL10-, granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF). Results: Mucosal innate and adaptive cytokines, chemokines and growth factors did not differ between self-reported NCGS, treated CD and controls. On the contrary, IL-6, IL-15, IL-27, IFN-alpha, IFN-gamma, IL-17A, IL-23, G-CSF, GM-CSF, IL-8, CCL1 and CCL4 were significantly higher in untreated CD than in self-reported NCGS, treated CD and controls, while TSLP was significantly lower in untreated CD than in self-reported NCGS, treated CD and controls. Conclusion: In our hands, patients with self-reported NCGS showed no abnormalities of the mucosal immune response. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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