期刊
JOURNAL OF NATURAL PRODUCTS
卷 84, 期 3, 页码 932-948出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c01237
关键词
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资金
- National Institutes of Health [CA12831, CA 23857, CA 40771, CA 48974, CA 55131, TW00313, CA69571, AT008088]
- National Science Foundation [PCM-89111508]
- American Cancer Society [CH268]
- SmithKline Animal Health Products
- Bristol-Myers Squibb
The author discusses his 60-year career in studying the chemistry of natural products, including structural, synthetic, and biosynthetic studies of various natural products like insect pigments, antibiotics, fecal mutagens, taxol, anticancer drugs, and antimalarial drugs. One compound, napabucasin, is highlighted as now being in phase III clinical trials as an anticancer drug.
The author describes his 60-year career in studying the chemistry of natural products, which includes structural, synthetic, and biosynthetic studies of natural products ranging from insect pigments, antibiotics, and fecal mutagens to taxol and other anticancer natural products as well as antimalarial natural products. One of the compounds discussed, napabucasin, is now an anticancer drug in phase III clinical trials.
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