Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertension

Although essential hypertension affects a large proportion of the human population and is one of the key drivers of cardiovascular mortality worldwide, we still do not have a complete understanding of its pathophysiology. More than 50 years ago, the immune system has been identified as an important part of the pathogenesis of arterial hypertension. An exceeding variety of recent publications deals with the interplay between the numerous different components of the immune system and mechanisms of arterial hypertension and has substantially contributed to our understanding of the role of immunity and inflammation in the pathogenesis of the disease. In this review, we focus on myeloid cells and anatomical barriers as particular aspects of innate immunity in arterial hypertension. Since it represents a first line of defense protecting against pathogens and maintaining tissue homeostasis, innate immunity provides many mechanistic hinge points in the area of hypertension.

Automated summary

Essential hypertension is a major factor in cardiovascular mortality worldwide, but its pathophysiology is not fully understood. The immune system has been identified as an important part of the pathogenesis of arterial hypertension. Recent publications have focused on the interplay between different components of the immune system and mechanisms of arterial hypertension, contributing to our understanding of the role of immunity and inflammation in the disease's pathogenesis.