Investigation of the thermodynamic and compressibility properties of antihypertensive drug Hydralazine hydrochloride in aqueous and aqueous amino acids solutions at various temperatures

In present communication we report experimental density and speed of sound data for the antihypertensive drug Hydralazine hydrochloride in water and 0.05 mol.kg(-1) L-alanine and L-valine aqueous solutions at temperatures 293.15, 298.15, 303.15,308.15 and 313.15 K within the molality range of 0.06-0.15 mol.kg(-1). By using the experimental density and speed of sound data and appropriate equations, we calculate the parameter like apparent molar volume of solute(V-phi), limiting apparent molar volume of solute (V-phi(0)), apparent molar expansivity(E-phi), isobaric expansivity coefficient (alpha), limiting apparent molar expansivity(E-phi(0)), isentropic compressibility(K-s), apparent molar isentropic compressibility of solute(K-s,K-phi) apparent molar isentropic compressibility at the infinite dilutions(K-S,phi(0)), and hydration nurnber(n(h)). The limiting apparent molar volume of solute has been used to obtain transfer parameter for Hydralazine hydrochloride. The hydration behavior for the experimental studied drug in the different mediums has been understood by computing the hydration number. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

In this study, experimental density and speed of sound data for the antihypertensive drug Hydralazine hydrochloride in water and two amino acid aqueous solutions were reported. Various parameters were calculated to understand the hydration behavior of the drug in different mediums.