期刊
JOURNAL OF MEMBRANE SCIENCE
卷 618, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.memsci.2020.118740
关键词
Polyethersulfone; Heparin mimicking semi-interpenetrating; In-situ cross-linking polymerization; Alkali-induced phase separation; Hemocompatibility
资金
- Fundamental Research Funds for the Central Universities and Graduate Student Innovation Fund of Donghua University [CUSF-DH-D-2019013]
- Natural Science Foundation of China [51873034]
The study introduces a method of incorporating analogous heparin polymers into composite polyethersulfone (PES) membranes, which exhibit excellent hemocompatibility and tunable permeability, while demonstrating superb anti-protein adsorption, platelet adhesion inhibition, hemolysis reduction, and clotting time prolongation effects.
Natural heparin macromolecule has been widely used to improve the hemocompatibility of biomaterials. However, heparin can cause spontaneous bleeding in some patients, which is troublesome for clinical applications. Fortunately, analogous heparin polymers have shown promise to replace heparin. Here a new class of composite polyethersulfone (PES) membranes were constructed, which offered tunable permeability together with excellent hemocompatibility via incorporating heparin-mimicking semi-interpenetrating polymer. The polyurethane macromer was synthesized as an effective cross-linker to incorporate functional polyacrylic acid and poly-2-acrylanmido-2-methylpropanesulfonic acid segments into PES solution through in-situ cross-linking polymerization. Then the heparin-mimicking semi-interpenetrating composite PES membranes were fabricated from the resulting casting solution via alkali-induced phase separation technique. The resulting composite membranes showed excellent inhibition of protein adsorption, suppression of platelet adhesion, reduction of hemolysis ratio and prolongation of clotting times, while displayed high hydrophilicity, permeability and clearance to urea, creatinine and lysozyme. Interestingly, the composite membranes also exhibited excellent mechanical properties due to the synergistic effect of polyurethane composition and in-situ cross-linking co-polymerization. To further demonstrate the applicability and effectiveness of this method, a composite PES hollow fiber with excellent ultrafiltration and mechanical properties was also fabricated. This straightforward and facile method is constructed as an ideal candidate to suppress blood clotting for a range of blood purification membrane-related applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据