Maternal serum split and hairy-related protein 1 in preeclampsia versus normal pregnancy

Objective The primary objective was to compare maternal serum split and hairy related protein-1 (SHARP1) in preeclamptic women versus normal pregnant women. The secondary objectives were to compare maternal and neonatal outcomes between preeclampsia and normal pregnant women. Methods This cross-sectional analytic study included 75 preeclamptic pregnant women and 75 normal pregnant women at Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital between March 2018 and May 2019. Blood was collected into nonheparinized tubes. Blood samples were centrifuged and stored at -80 degrees C until assayed. Maternal serum SHARP1 levels were measured by enzyme-linked immunosorbent assays. Maternal and neonatal outcomes were recorded. Results Median serum SHARP1 level in preeclampsia was significantly higher than in normal pregnancy (5.2 vs. 3.7 ng/mL, p = .007). Preeclamptic women had a higher rate of cesarean section than normal pregnant women (68% vs. 32%, p < .001). Preeclamptic women had lower neonatal birth weight than normal pregnant women (2,546.1 +/- 766.3 vs 2,884.5 +/- 479.9, p = .001). Neonatal complications were higher in preeclamptic women than normal pregnant women (40% vs. 17.3%, p = .002). Conclusions Serum SHARP1 in preeclampsia was significantly higher than in normal pregnancy.

Automated summary

This study compared the levels of SHARP1 in preeclamptic women and normal pregnant women, and found that preeclamptic patients had higher levels of SHARP1. Additionally, preeclamptic women had higher rates of cesarean section, lower neonatal birth weight, and higher rates of neonatal complications compared to normal pregnant women.