期刊
JOURNAL OF LIPOSOME RESEARCH
卷 31, 期 4, 页码 389-398出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08982104.2020.1849280
关键词
Liposome; chitosan; carbamazepine; coenzyme Q10; epilepsy
资金
- Bezmialem Vakif University Research Fund [6.2017/52]
The study successfully developed chitosan-coated liposomal formulations encapsulating CBZ and CoQ10 with high encapsulation efficiency, particle size, and drug release characteristics, offering a promising approach for the treatment of epilepsy.
Conventional formulations cannot sufficiently control seizures and influence on cognitive corruption and oxidative stress with chronic usage in patients with epilepsy. To defeat this issue, it was planned to develop polymeric liposome formulations that are using for their bioavailability and enhancer impact in oral epilepsy treatment. In this study, chitosan-coated liposomal formulations that encapsulate carbamazepine (CBZ) and coenzyme Q10 (CoQ10) were prepared and optimized by utilizing response surface methodology (RSM). Encapsulation efficiencies of CBZ and CoQ10, which were chosen as dependent variables for optimized chitosan-coated liposomal formulations were determined as 76.13%+/- 2.34% and 82.36%+/- 3.15%, respectively. Narrow size distribution was provided with an average size of 187.1 +/- 2.35 nm, while a spherical and uniform shape was approved with transmission electron microscopy analyses. Cumulative release of 78.23% for CBZ and 27.12% for CoQ10 was obtained after 24 hours of in-vitro release study in sink conditions. Physical stability analyses demonstrated that optimum liposomes were convenient for storage at 5 +/- 3 degrees C for at least 90 days. As a result, optimum chitosan-coated liposome containing CBZ and CoQ10 formulations could be suggested as a hopeful approach concerning their release, particle size, high encapsulation efficiency and stability for the treatment of epilepsy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据