期刊
JOURNAL OF INFECTIOUS DISEASES
卷 224, 期 3, 页码 443-452出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa763
关键词
human immunodeficiency virus; liver disease; transient elastography; hepatotoxicity; NAFLD
资金
- Simonsen Foundation
- Novo Nordisk Foundation
- Lundbeck Foundation
- Rigshospitalet Research Council
- Region Hovedstaden
- Danish National Research Foundation [126]
The prevalence of elevated liver stiffness measurement (LSM) was higher in people with HIV compared to population controls. Factors independently associated with elevated LSM included older age, higher BMI, elevated ALT levels, previous exposure to didanosine, and positive HIV status.
Background. Liver fibrosis is associated with poor liver-related outcomes and mortality. People with human immunodeficiency virus (PWH) may be at increased risk. We aimed to estimate the prevalence and factors associated with liver fibrosis in PWH compared to population controls. Methods. This was a cross-sectional cohort study comparing 342 PWH with 2190 population controls aged 50-70 years. Transient elastography was performed and elevated liver stiffness measurement (LSM) defined as 7.6 kPa as a proxy for significant liver fibrosis. Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were computed by logistic regression. Results. The prevalence of elevated LSM was higher in PWH than in uninfected controls (12% vs 7%; P < .01). Human immunodeficiency virus (HIV) infection was independently associated with elevated LSM. In multivariate analysis, elevated LSM was associated with HIV (aOR, 1.84 [95% CI, 1.17-2.88]; P < .01); higher age (per decade: aOR, 3.34 [95% CI, 1.81-6.18]; P < .01); alanine aminotransferase (ALT) (per 10 IU/L: aOR, 1.25 [95% CI, 1.05-1.49]; P < .01); body mass index (BMI) (per 1 kg/m(2): aOR, 1.17 [95% CI, 1.05-1.29]; P < .01), and previous exposure to didanosine (per year: aOR, 2.26 [95% CI, 1.01-5.06]; P = .04). Conclusions. The prevalence of elevated LSM was higher in PWH compared to population controls. Higher age, BMI, ALT, previous exposure to didanosine, and positive HIV status were independently associated with higher odds of elevated LSM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据