期刊
JOURNAL OF INFECTIOUS DISEASES
卷 223, 期 5, 页码 805-810出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa744
关键词
SARS-CoV-2; monocytes; tumor necrosis factor; COVID-19
Levels of TNFR1 and TNFR2 in COVID-19 patients are associated with disease severity, and patients with lower levels of TNFR1 and TNFR2 are more likely to recover.
People infected with severe acute respiratory syndrome coronavirus 2 display a wide range of illness, from asymptomatic infection to severe respiratory distress resulting in death. We measured serum biomarkers in uninfected individuals and in individuals with mild, moderate, or critical coronavirus disease 2019 (COVID-19) disease. Levels of monocyte activation (soluble CD14 and fatty acid-binding protein 4) and inflammation (tumor necrosis factor receptors 1 and 2 [TNFR1 and TNFR2]) were increased in COVID-19 individuals, regardless of disease severity. Among patients with critical disease, individuals who recovered from COVID-19 had lower levels of TNFR1 and TNFR2 at hospital admission compared to these levels in patients with critical disease who ultimately died.
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