Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role

Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid organs, providing both a structural matrix and soluble factors that regulate survival and migration of immune cells, ultimately promoting Ag encounter. In several inflamed tissues, resident fibroblasts can acquire lymphoidstroma properties and drive the formation of ectopic aggregates of immune cells, named tertiary lymphoid structures (TLSs). Mature TLSs are functional sites for the development of adaptive responses and, consequently, when present, can have an impact in both autoimmunity and cancer conditions. In this review, we go over recent findings concerning both lymph node stromal cells and TLSs function and formation and further describe what is currently known about their role in disease, particularly their potential in tolerance.

Automated summary

This review focuses on the role of lymph node stromal cells and TLSs in coordinating adaptive immune responses and their potential impact on diseases, particularly autoimmunity and cancer. The discussion includes recent findings on the function and formation of these structures and their possible role in promoting tolerance.