期刊
JOURNAL OF HUMAN NUTRITION AND DIETETICS
卷 34, 期 3, 页码 585-594出版社
WILEY
DOI: 10.1111/jhn.12861
关键词
gastric cancer; neoadjuvant therapy; body composition changes; prognosis
资金
- National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences [2019PT320009]
- Beijing Municipal Science and Technology Commission Program [D171100006517002]
This study found that patients with gastric cancer undergoing radical gastrectomy have worse survival outcomes when experiencing significant loss of adipose tissue during neoadjuvant treatment. The loss of visceral adipose tissue and subcutaneous adipose tissue during treatment was associated with poorer overall survival and disease-free survival, while changes in skeletal muscle mass and body weight did not affect survival.
Background The influence of body composition changes during neoadjuvant treatment (NT) on long-term survival in patients with gastric cancer (GC) undergoing radical gastrectomy remains unclear. The present study aimed to explore the association between changes in body composition during NT and survival in patients with GC. Methods GC patients treated with NT and radical gastrectomy between 2015 and 2018 were included in this retrospective study. Skeletal muscle mass, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured by computer tomography before and after NT. Body composition changes during NT were compared with Kaplan-Meier curves. Univariate and multivariate regression analyses were applied to determine the predictors of overall survival (OS) and disease-free survival (DFS). Results In total, 157 GC patients were studied. A marked loss of adipose tissue was associated with poor nutritional status. The median follow-up time for all patients was 25 months. Patients with marked VAT loss (>= 35.7%) during NT had significantly shorter OS (p = 0.028) and DFS (p = 0.03). Similarly, poorer OS (p = 0.033) and DFS (p = 0.003) were observed in patients with marked SAT loss (>= 30.1%) during NT. Changes in skeletal muscle mass and body weight during NT were not associated with survival. Marked VAT loss accompanied by marked SAT loss was an independent predictor of OS (hazards ratio = 2.447; p = 0.045) and DFS (hazards ratio = 2.674; p = 0.018). Conclusions Patients with locally advanced GC have a worse survival when they experienced marked loss of adipose tissue during NT.
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