期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 218, 期 4, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20202187
关键词
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资金
- National Key Research and Development Programof China [2018YFC1200100, 2020YFC0842400]
- National Natural Science Foundation of China [82025001, 91842106, 81901623]
- Ministries of Science and Technology of Guangdong Province [2020B1111330001, 2020A111128008, 2020B1111320003, B195001248]
- Ministries of Education of Guangdong Province [2020KZDZX1158]
- Science and Technology Planning Project of Guangzhou [202008040005]
- Science and Technology Planning Project of Guangdong Province [2018A030310177]
- State Key Laboratory of Respiratory Disease Science and Technology Foundation [SKLRD-QN-201912]
This study identified SARS-CoV-2-specific T cell epitopes and demonstrated the important role of virus-specific T cells in the immune response after SARS-CoV-2 infection, particularly in regulating immune responses. T cell vaccination alone partially protected SARS-CoV-2-infected mice from severe disease.
Virus-specific T cells play essential roles in protection against multiple virus infections, including SARS-CoV and MERS-CoV. While SARS-CoV-2-specific T cells have been identified in COVID-19 patients, their role in the protection of SARS-CoV2-infected mice is not established. Here, using mice sensitized for infection with SARS-CoV-2 by transduction with an adenovirus expressing the human receptor (Ad5-hACE2), we identified SARS-CoV-2-specific T cell epitopes recognized by CD4(+) and CD8(+) T cells in BALB/c and C57BL/6 mice. Virus-specific T cells were polyfunctional and were able to lyse target cells in vivo. Further, type I interferon pathway was proved to be critical for generating optimal antiviral T cell responses after SARS-CoV-2 infection. T cell vaccination alone partially protected SARS-CoV-2-infected mice from severe disease. In addition, the results demonstrated cross-reactive T cell responses between SARS-CoV and SARS-CoV-2, but not MERS-CoV, in mice. Understanding the role of the T cell response will guide immunopathogenesis studies of COVID-19 and vaccine design and validation.
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