期刊
DIAGNOSTIC PATHOLOGY
卷 11, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13000-016-0497-z
关键词
Pancreas; Pancreatic cancer; Acinar cell carcinoma; Pancreatic neuroendocrine tumor; Solid-pseudopapillary neoplasm; Genetics; Histology; Methylation; microRNA; Sequencing
类别
资金
- Myriad Genetics
- Board of MiDiagnostics
Background: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. Main body: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment. Conclusion: This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma.
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