期刊
JOURNAL OF DRUG TARGETING
卷 29, 期 4, 页码 403-419出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1061186X.2020.1853759
关键词
Chalcones; viral infections; COVID-19; HIV; influenza virus; HSV; hepatitis B virus; rhino virus; dengue virus
资金
- Qatar National Library
- Qatar University [QUCG-CPH-20/21-4, QUHI-CMED-19/20-1, QUCG-CMED-20/21-2]
This review provides a summary of the antiviral activities of chalcones and their derivatives on a set of human viral infections and their potential for targeting the most recent COVID-19 disease. Studies have shown that chalcones have various pharmacological activities, including antiviral, anti-inflammatory, antimicrobial, and anticancer effects.
Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that can overcome the limitations of currently marketed antiviral drugs. Chalcones are natural open chain flavonoids that are found in various plants and can be synthesised in labs. Several studies have shown that these small organic molecules exert a number of pharmacological activities, including antiviral, anti-inflammatory, antimicrobial and anticancer. The purpose of this review is to provide a summary of the antiviral activities of chalcones and their derivatives on a set of human viral infections and their potential for targeting the most recent COVID-19 disease. Accordingly, we herein review chalcones activities on the following human viruses: Middle East respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus, human immunodeficiency, influenza, human rhinovirus, herpes simplex, dengue, human cytomegalovirus, hepatitis B and C, Rift Valley fever and Venezuelan equine encephalitis. We hope that this review will pave the way for the design and development of potentially potent and broad-spectrum chalcone based antiviral drugs.
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