期刊
JOURNAL OF DERMATOLOGY
卷 48, 期 3, 页码 413-417出版社
WILEY
DOI: 10.1111/1346-8138.15698
关键词
mycoses; phaeohyphomycosis; sequence analysis | systemic antifungals
类别
Three rare cases of Pleosporales deep cutaneous infections were reported in a medical center in southern Taiwan. The patients, all elderly individuals living in rural tropical areas, presented with erythematous noduloplaques on their upper extremities. Treatment with oral itraconazole showed successful outcomes in two cases, while one case showed partial improvement but did not complete the treatment. Molecular tools were crucial for accurate species identification and successful treatment of DCFI.
Deep cutaneous fungal infections (DCFI) are cutaneous and subcutaneous infectious diseases caused by fungi. Multiple genera of pathogenic fungi have been reported to cause DCFI. Herein, we report three rare cases of Pleosporales deep cutaneous infection in a southern Taiwan medical center. We evaluated the clinical manifestations, histopathological findings, pathogens, treatments and outcomes. The patients were a 77-year-old woman, a 78-year-old woman and an 81-year-old man, who lived in rural tropical areas. The lesions were erythematous noduloplaques with dark spots located on the upper extremities. Sequence-based identification showed three different fungi of the order Pleosporales, namely Nigrograna mackinnonii, Medicopsis romeroi and Parathyridaria percutanea. All three cases received 200 mg of oral itraconazole daily for 10, 2 and 8 months, respectively. Two of them are free of diseases to date, and one improved partially but did not complete the treatment. Molecular tools are helpful for the identification of DCFI to exact species, which is key to successful treatment.
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