期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 86, 期 1, 页码 86-92出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2016.06.016
关键词
PNA FISH; Rapid diagnostics; Antibiotic stewardship; Bacteremia
资金
- AdvanDx, Inc. (Woburn, MA)
Peptide nucleic acid fluorescence in situ hybridization (PNA FISH) is a rapid diagnostic assay that can identify certain organisms growing in blood cultures 30-90 min from the time of positive Gram-stain. Existing studies have demonstrated a clinical utility with this assay when antibiotic stewardship programs assist clinicians with interpreting the results. However, the benefit of these rapid assays in the absence of concomitant antibiotic stewardship involvement is unclear. In this randomized study of 220 patients with enterococcal or streptococcal bacteremia, we found that PNA FISH, in the absence of concomitant input from an antibiotic stewardship program, had no impact on time to effective or optimal therapy, length of hospital stay, or in-hospital mortality. Our results suggest that in the absence of guidance from an antibiotic stewardship program, the clinical benefits of rapid diagnostic microbiological tools may be reduced. (C) 2016 Elsevier Inc. All rights reserved.
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