期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 86, 期 2, 页码 243-248出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2016.07.002
关键词
ESBL, extended spectrum beta-lactamase; MIC, minimum inhibitory concentration; CRE, carbapenem-resistant Enterobacteriaceae
资金
- Senosiain
- Pfizer
- Merck Sharp Dhome
- Sanofi Pasteur
- AstraZeneca
- bioMerieux
We describe the outcomes and factors associated with OXA-232 producing carbapenem-resistant Enterobacteriaceae infections. A case-control-control study was performed; each case of infection by a carbapenem-resistant/OXA-232 (OXA-232-cases, n = 27) was matched by isolation site, species, and date, with 2 cases of infection by carbapenem-susceptible/third-generation cephalosporin-susceptible (TGCS-controls, n = 54) and 2 cases by carbapenem-susceptible/ESBL producing Enterobacteriaceae (ESBL-controls, n = 54); 66% were urinary tract and 18.5% intra-abdominal infections. In the multivariable analysis with ESBL-controls, previous use beta-lactam/beta-lactamase antibiotics (OR 6.2; 95% CI 1.6-23.8) and, third-generation cephalosporins (OR 0.2; 95% CI 0.05-0.8) were associated with OXA-232 infection; with TGSC-controls previous use of beta-lactam/beta-lactamase antibiotics (OR 3.7; 95% 1.1-12.0) was associated. Among the OXA-232-cases, 29% received imipenem/cilastatin or meropenem, 11.1% ceftriaxone, 22.2% a carbapenem-based combination and 33.3% other antimicrobials as treatment. Previous beta-lactam/beta-lactamase antibiotics are associated with OXA-232 infections, and some may be treated with other active carbapenems or, in the absence of ESBL, third-generation cephalosporins. (C) 2016 Elsevier Inc. All rights reserved.
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