期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 86, 期 2, 页码 172-177出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2016.07.011
关键词
Candida africana; Candida albicans; Candida dubliniensis; Candida metapsilosis; Candida orthopsilosis; Candida parapsilosis; Caspofungin; Echinocandins; Postantifungal effect
资金
- Consejerla de Educacion, Universidades e Investigacion [GIC12 210-IT-696-13]
- Departamento de Industria, Comercio y Turismo of Gobierno Vasco-Eusko Jaurlaritza [S-PR12UN002, S-PE13UN121]
- Fondo de Investigacion Sanitaria [FIS PI11/00203]
- UPV/EHU [UFI 11/25]
- Astellas Pharma
- Pfizer
- Gilead Sciences
- Merck Sharp and Dohme
- Abbvie
Killing and postantifungal effects could be relevant for the selection of optimal dosing schedules. This study aims to compare time-kill and postantifungal effects with caspofungin on Candida albicans (C. albicans, Candida dubliniensis, Candida africana) and Candida parapsilosis (C. parapsilosis, Candida metapsilosis, Candida orthopsilosis) clades. In the postantifungal effect experiments, strains were exposed to caspofungin for 1 h at concentrations 0.12-8 mu g/mL. Time-kill experiments were conducted at the same concentrations. Caspofungin exhibited a significant and prolonged postantifungal effect (>37 h) with 2 mu g/mL against the most strains of C albicans dade. Against the C parapsilosis Glade, the postantifungal effect was <12 hat 8 mu g/mL, except for two strains. Caspofungin was fungicidal against C albicans, C dubliniensis and C metapsilosis. (C) 2016 Elsevier Inc. All rights reserved.
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