期刊
JOURNAL OF CLINICAL ONCOLOGY
卷 39, 期 2, 页码 116-+出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1200/JCO.20.00386
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资金
- French Ministry of Health, Soutien aux Techniques Innovantes Couteuses 2010 Cancer [STIC 10/03]
- French National Agency for Research [ANR-11-LABX-0018-01]
- ArronaxPlus Equipex [ANR-11-EQPX-0004]
- SIRIC ILIAD [INCa-DGOS-Inserm_12558]
This study analyzed the metabolic response of PET/CT scans in newly diagnosed transplantation-eligible patients with multiple myeloma, and found that FL and bone marrow FDG uptake lower than liver background could predict prolonged progression-free survival and overall survival, suggesting their value as standardized criteria for PET complete metabolic response in patients with MM.
PURPOSE F-18-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is currently the standard technique to define minimal residual disease (MRD) status outside the bone marrow (BM) in patients with multiple myeloma (MM). This study aimed to define criteria for PET complete metabolic response after therapy, jointly analyzing a subgroup of newly diagnosed transplantation-eligible patients with MM enrolled in two independent European randomized phase III trials (IFM/DFCI2009 and EMN02/HO95). PATIENTS AND METHODS Two hundred twenty-eight patients were observed for a median of 62.9 months. By study design, PET/CT scans were performed at baseline and before starting maintenance (premaintenance [PM]). The five-point Deauville scale (DS) was applied to describe BM (BM score [BMS]) and focal lesion (FL; FL score [FS]) uptake and tested a posteriori in uni- and multivariable analyses for their impact on clinical outcomes. RESULTS At baseline, 78% of patients had FLs (11% extramedullary), 80% with an FS >= 4. All patients had BM diffuse uptake (35.5% with BMS >= 4). At PM, 31% of patients had visually detectable FLs (2% extramedullary), 24% and 67.7% of them with an FS of 3 and >= 4, respectively. At PM, 98% of patients retained residual BM diffuse uptake, which was significantly lower than at baseline (mainly between BMS 2 and 3, BMS was >= 4 in only 8.7% of patients). By both uni- and multivariable analysis, FS and BMS, <4 were associated with prolonged progression-free survival (PFS) and overall survival (OS) at PM (OS: hazard ratio [HR], 0.6 and 0.47, respectively; PFS: HR, 0.36 and 0.24, respectively) CONCLUSION FL and BM FDG uptake lower than the liver background after therapy was an independent predictor for improved PFS and OS and can be proposed as the standardized criterion of PET complete metabolic response, confirming the value of the DS for patients with MM. (C) 2020 by American Society of Clinical Oncology
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