期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 106, 期 5, 页码 E2151-E2161出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgab028
关键词
ghrelin; glucagon; glycemic load; satiety; hunger; appetite
资金
- National Institute of Child Health and Human Development [RO1HD054960]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR003096]
- National Institute of Diabetes and Digestive and Kidney Diseases [P30DK056336, P60DK079626]
- T32 Predoctoral Award from the UAB Predoctoral Training Program in Obesity-Related Research [T32HL105349]
- T32 Post-doctoral Award from the UAB Postdoctoral Training Program in Obesity-Related Research [T32DK062710]
The study suggests that in women with PCOS who have adapted to a low GL diet, a low GL meal can reduce ghrelin and increase glucagon. Further research is needed to determine the influence of diet composition on ad libitum intake in women with PCOS.
Context: Altered satiety hormones in women with polycystic ovarian syndrome (PCOS) may contribute to obesity. Diets with a low glycemic load (GL) may influence appetite-regulating hormones including glucagon and ghrelin. Objective: To test the hypothesis that following a 4-week, eucaloric low vs high GL diet habituation, a low vs high GL meal will increase glucagon and decrease ghrelin to reflect greater satiety and improve self-reported fullness. Methods: Secondary analysis of a randomized crossover trial. Participants: Thirty women diagnosed with PCOS. Intervention: Participants were provided low (41:19:40% energy from carbohydrate:protein:fat) and high (55:18:27) GL diets for 8 weeks each. At each diet midpoint, a solid meal test was administered to examine postprandial ghrelin, glucagon, glucose, insulin, and self-reported appetite scores. Results: After 4 weeks, fasting glucagon was greater with the low vs high GL diet (P =.035), and higher fasting glucagon was associated with lesser feelings of hunger (P =.009). Significant diet effects indicate 4-hour glucagon was higher (P < .001) and ghrelin was lower (P =.009) after the low vs high GL meal. A trending time x diet interaction (P = .077) indicates feelings of fullness were greater in the early postprandial phase after the high GL meal, but no differences were observed the late postprandial phase. Conclusion: These findings suggest after low GL diet habituation, a low GL meal reduces ghrelin and increases glucagon in women with PCOS. Further research is needed to determine the influence of diet composition on ad libitum intake in women with PCOS.
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