期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1634, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.chroma.2020.461671
关键词
Q-TOF; Multi-residue analysis; Veterinary drugs; Pork; Metabolite
资金
- Science and technology joint research projects of Yangtze River Delta from Shanghai Science and Technology Committee [18395810300]
A rapid, simple and generic analytical method has been developed for the analysis of veterinary drugs in pork by a quadrupole time-of-flight mass spectrometry (Q-TOF MS). This method allows for the simultaneous identification, screening and quantitation of 141 veterinary drug residues and metabolites from eighteen different classes. After extraction with acetonitrile/water and clean-up with C-18 cartridges, the samples were analyzed by HPLC-Q-TOF MS. Validation of this method consisted of confirmation of identity, selectivity, linearity, limit of detection (LOD), lowest limit of quantification (LLOQ), matrix effect, recovery, precision and applicability of the method. Identification of the analytes was based on accurate mass measurements. The characteristic fragments were obtained by collisional experiments for a more reliable identification. The procedure was then applied to real pork samples. Sulfamethazine was detected in one sample and its metabolites were successfully found in one single run. This approach proved to be satisfactory for routine analysis. (C) 2020 Elsevier B.V. All rights reserved.
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