期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1636, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.chroma.2020.461792
关键词
Capillary column; Metal organic cage; Chiral stationary phase; Gas chromatography; Chiral separation
Chiral metal-organic cages (MOCs) have been investigated as a novel stationary phase for gas chromatography (GC) due to their unique molecular recognition ability. The chiral MOC-PA exhibited high-resolution performance for a wide range of analytes, especially for amino acid derivatives, showing excellent separation repeatability and reproducibility. The experimental results suggest that MOC-PA has great potential as a GC stationary phase.
Chiral metal-organic cages (MOCs) are a new type of porous materials with unique molecular recognition ability, which have received research attention as a chiral stationary phase (CSP) for gas chromatography (GC). Herein, we report the detailed investigation of a chiral MOC ([Cu-12(L-pA)(12)(H2O)(12)], PA = L-phenylalanine, MOC-PA) as a novel stationary phase for GC separations. The MOC-PA capillary column exhibited a high-resolution performance for a wide range of analytes, including n-alkanes, n-alcohols, esters, aromatic compounds and the Grob mixture, positional isomers and racemates. In particular, MOCPA coated column displayed good resolution and performance for amino acid derivatives. Moreover, the MOC-PA column showed excellent separation repeatability and reproducibility. The relative standard deviation (RSD) values for the retention times were in the range of 0.16-0.30% for run to run (n = 3), 0.31-0.77% for day-to-day (n = 3), and 3.6-4.7% for column-to-column (n = 3), respectively. The experimental results showed that MOC-PA had great potential as a GC stationary phase. (C) 2020 Elsevier B.V. All rights reserved.
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