期刊
JOURNAL OF CHILD NEUROLOGY
卷 36, 期 7, 页码 525-529出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073820984067
关键词
children; epilepsy; ketogenic diet; pediatric; treatment
资金
- EpLink -The Epilepsy Research Program of the Ontario Brain Institute (OBI)
- Ontario government
The study found that children with epilepsy undergoing ketogenic diet therapy may experience neutropenia. Factors such as high urinary ketones and longer duration of diet therapy were associated with neutropenia, but it was not linked to the development of infections.
Objectives: The objectives were to investigate the relationship between ketogenic diet therapy and neutropenia in children with epilepsy. Methods: A retrospective chart review of children who initiated ketogenic diet at the Hospital for Sick Children between January 1, 2000, and May 1, 2018 was performed. Factors associated with the development of neutropenia during ketogenic diet therapy were evaluated and the relationship between development of a significant or suspected infection and neutrophil count was analyzed. Results: One hundred two children met inclusion criteria and were followed on the diet for up to 24 months. Thirteen of 102 (13%) children were neutropenic at diet initiation. In the remaining 89 children, 27 developed neutropenia. Developing neutropenia was significantly associated with the ketogenic diet at 6 (13%), 12 (23%), and 24 (25%) months follow-up. Developing neutropenia was associated with higher urinary ketones (OR = 4.26, 95% CI: 1.27, 14.15) and longer duration of ketogenic diet therapy (OR = 3.29, 95% CI: 1.42, 7.96). There was no significant association between development of a clinically significant infection and neutropenia. Conclusion: Ketogenic diet therapy is associated with neutropenia in children with epilepsy, however, it does not have a significant clinical impact. Concern regarding neutropenia should not discourage the use of the ketogenic diet in children.
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