期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 41, 期 8, 页码 1954-1963出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X20982389
关键词
Deep brain stimulation; symptoms; Parkinson's disease; positron emission tomography; serotonin (5-HT)
资金
- Lundbeck Foundation [R170 2014 994, R183 2014 3836]
- Aase and Ejnar Danielsens Fond [10-001296]
- Fonden til Laegevidenskabens Fremme [13-216]
This study demonstrates that DBS-STN dynamically regulates the serotonin system in PD, and the preservation of serotonin function may predict the effects of DBS-STN.
Patients with Parkinson's disease (PD) often suffer from non-motor symptoms, which may be caused by serotonergic dysfunction. Apart from alleviating the motor symptoms, Deep Brain Stimulation (DBS) in the subthalamic nucleus (STN) may also influence non-motor symptoms. The aim of this study is to investigate how turning DBS off affects the serotonergic system. We here exploit a novel functional PET neuroimaging methodology to evaluate the preservation of serotonergic neurons and capacity to release serotonin. We measured cerebral 5-HT1BR binding in 13 DBS-STN treated PD patients, at baseline and after turning DBS off. Ten age-matched volunteers served as controls. Clinical measures of motor symptoms were assessed under the two conditions and correlated to the PET measures of the static and dynamic integrity of the serotonergic system. PD patients exhibited a significant loss of frontal and parietal 5-HT1BR, and the loss was significantly correlated to motor symptom severity. We saw a corresponding release of serotonin, but only in brain regions with preserved 5-HT1BR, suggesting the presence of a presynaptic serotonergic deficit. Our study demonstrates that DBS-STN dynamically regulates the serotonin system in PD, and that preservation of serotonergic functions may be predictive of DBS-STN effects.
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