期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 41, 期 8, 页码 1886-1898出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X20978582
关键词
Low frequency oscillation; cerebrovascular reactivity; hemodynamic response; hypercapnia; BOLD signal
资金
- National Institutes of Health [K25 DA031769]
- Indiana Clinical and Translational Sciences Institute
This study developed a novel analytical method to accurately calculate the arrival time of elevated CO2 at each voxel and used 26 candidate hemodynamic response functions to quantitatively describe the temporal brain reactions to a CO2 stimulus. By improving the traditional method, this approach successfully mapped three perfusion-related parameters: the relative arrival time of blood, the hemodynamic response function, and CVR during a CO2 challenge.
Elevated carbon dioxide (CO2) in breathing air is widely used as a vasoactive stimulus to assess cerebrovascular functions under hypercapnia (i.e., stress test for the brain). Blood-oxygen-level-dependent (BOLD) is a contrast mechanism used in functional magnetic resonance imaging (fMRI). BOLD is used to study CO2-induced cerebrovascular reactivity (CVR), which is defined as the voxel-wise percentage BOLD signal change per mmHg change in the arterial partial pressure of CO2 (PaCO2). Besides the CVR, two additional important parameters reflecting the cerebrovascular functions are the arrival time of arterial CO2 at each voxel, and the waveform of the local BOLD signal. In this study, we developed a novel analytical method to accurately calculate the arrival time of elevated CO2 at each voxel using the systemic low frequency oscillations (sLFO: 0.01-0.1 Hz) extracted from the CO2 challenge data. In addition, 26 candidate hemodynamic response functions (HRF) were used to quantitatively describe the temporal brain reactions to a CO2 stimulus. We demonstrated that our approach improved the traditional method by allowing us to accurately map three perfusion-related parameters: the relative arrival time of blood, the hemodynamic response function, and CVR during a CO2 challenge.
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