期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 25, 期 4, 页码 2279-2284出版社
WILEY
DOI: 10.1111/jcmm.16269
关键词
Metformin; Obese asthma; Tregs
资金
- National Nature Science Foundation of China [81670022, 81803636, 8170010835]
- Nature Science Foundation of Guangdong Province [2017A030313822, 2018A0303130329]
- Guangzhou Science and Technology Program Key Project [201704020123, 202008040003]
- Guangdong Key Technology R&D Program for Controlling 2019 n-Cov [2020B111105001]
Obese asthmatic mice showed more severe airway inflammation and significant changes in inflammatory cytokines. Metformin reversed obesity, alleviated airway inflammation and remodeling with increased Tregs, suggesting potential anti-inflammatory effects through Treg modulation.
Obesity increases the morbidity and severity of asthma, with poor sensitivity to corticosteroid treatment. Metformin has potential effects on improving asthma airway inflammation. Regulatory T cells (Tregs) play a key role in suppressing the immunoreaction to allergens. We built an obese asthmatic mouse model by administering a high-fat diet (HFD) and ovalbumin (OVA) sensitization, with daily metformin treatment. We measured the body weight and airway inflammatory status by histological analysis, qRT-PCR, and ELISA. The percentage of Tregs was measured by flow cytometry. Obese asthmatic mice displayed more severe airway inflammation and more significant changes in inflammatory cytokines. Metformin reversed the obese situation and alleviated the airway inflammation and remodelling with increased Tregs and related transcript factors. The anti-inflammatory function of metformin may be mediated by increasing Tregs.
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