期刊
JOURNAL OF CELL SCIENCE
卷 134, 期 2, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.247056
关键词
Autophagy; Selective Autophagy; Cancer; Metastasis
类别
资金
- National Cancer Institute [CA201849, CA126792, CA213775, F31CA217015]
- Department of Defense BCRP [W81XWH-11-1-0130]
- Samuel Waxman Cancer Research Foundation
- Mark Foundation for Cancer Research (Endeavor Award)
- Pancreas Center Pilot Project Grant Award
- University of California San Francisco (UCSF)
Autophagy plays complex roles in cancer metastasis, affecting therapeutic approaches. It can both promote tumor growth and drug resistance, as well as inhibit the proliferation of disseminated tumor cells to form metastases.
Autophagy is deregulated in many cancers and represents an attractive target for therapeutic intervention. However, the precise contributions of autophagy to metastatic progression, the principle cause of cancer-related mortality, is only now being uncovered. While autophagy promotes primary tumor growth, metabolic adaptation and resistance to therapy, recent studies have unexpectedly revealed that autophagy suppresses the proliferative outgrowth of disseminated tumor cells into overt and lethal macrometastases. These studies suggest autophagy plays unexpected and complex roles in the initiation and progression of metastases, which will undoubtedly impact therapeutic approaches for cancer treatment. Here, we discuss the intricacies of autophagy in metastatic progression, highlighting and integrating the pleiotropic roles of autophagy on diverse cell biological processes involved in metastasis.
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