期刊
JOURNAL OF BIOPHOTONICS
卷 14, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202000426
关键词
ANCA‐ associated vasculitis; biomarker; disease activity; Raman spectroscopy
资金
- Renal Department at Royal Preston Hospital Lancashire NHS Foundation Trust
Raman spectroscopy is confirmed to be a novel and cost-effective biomarker that can discriminate active disease from remission in AAV patients with excellent accuracy, showing good group separation and high degree of accuracy.
Identifying persistent or relapsing disease in anti-neutrophil cytoplasmic autoantibody- associated vasculitis (AAV) remains a clinical challenge with an unmet need for a reliable biomarker of multisystem disease. In this study, we confirm for the first time that Raman spectroscopy offers a novel cost-effective candidate biomarker to discriminate active disease from remission in AAV with excellent accuracy. Spectrochemical interrogation of plasma and serum samples demonstrated equal ability to discriminate disease activity with good group separation on PC1 direction and a high degree of accuracy on validation testing using blind predictive modelling: F-score 80% for plasma (specificity 93.3%, sensitivity 70%, AUC 0.95) and 80% for serum (specificity 80%, sensitivity 80%, AUC 0.92). Similar findings were seen on analysis of paired remission samples following successful remission-induction therapy. A larger study with longitudinal data is required to validate these findings with the potential to aid patient care.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据