期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 109, 期 8, 页码 1105-1115出版社
WILEY
DOI: 10.1002/jbm.b.34773
关键词
contrast agent; gadolinium; Gd-DOTA; relaxivity; zeolite
资金
- Diagnostic and Interventional Imaging Department at McGovern Medical School-UTHealth
- CNPEM/LNBio-National Research Centre for Energy and Materials [RMN-22793]
- CAPES [88881.189630/2018-01]
- National Council for Scientific and Technological Development [406761/2013-2, 465594/2014-0]
- Sao Paulo State Research Foundation (FAPESP) [19/01858-5, 11/51851]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [19/01858-5] Funding Source: FAPESP
This study compared the performance of gadolinium-based contrast agents synthesized using different zeolites with commercial gadoteric acid, and demonstrated the potential of gadolinium-loaded NaX for providing better image contrast in in vivo experiments. Clearance studies also showed the elimination of both gadolinium-loaded NaX and gadoteric acid from the body after 2 days, highlighting the promising use of gadolinium-loaded NaX as an MRI contrast agent.
Gadolinium-based contrast agents (CAs) were synthesized using faujasite zeolite (NaX) and zeolite beta (BEA) and their performances in vitro and in vivo were compared to the widely used commercial CA, gadoteric acid (Gd-DOTA). Magnetic resonance imaging (MRI) relaxometry studies (considering longitudinal [T-1] and transverse [T-2] relaxation times) were performed using Gd-DOTA and the zeolitic materials loaded with Gd3+. The Gd-loaded NaX, which presented large pores and cavities (7.35 and 11.24 angstrom, respectively), exhibited relaxivity values of around 52 mM(-1) s(-1), while BEA, which presented smaller pore and cavity diameters (5.95 and 6.68 angstrom, respectively) showed lower relaxivity values of similar to 4.8 mM(-1) s(-1). The effect of the Gd-loaded NaX as MRI CA was tested in vivo in Sprague-Dawley rats, employing a 7 T scanner, with comparison to Gd-DOTA MRI angiography. The relaxivity measurements showed that the Gd-loaded NaX (50 mM(-1) s(-1)) provided better image contrast than Gd-DOTA (5.1 mM(-1) s(-1)). Clearance studies of the CAs using urine and blood showed that both Gd-loaded NaX and Gd-DOTA were eliminated from the body after 2 days, demonstrating the potential of Gd-loaded NaX for use as an MRI CA.
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