期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 32, 期 6, 页码 813-832出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2020.1870323
关键词
Chitosan; rhamnolipids; nanoparticles; drug delivery systems; antimicrobial
资金
- Natural Science Foundation of Shandong Province [ZR2018MC010]
This study developed chitosan-PMLA nanoparticulate systems as carriers for antimicrobial glycolipid, exhibiting significant antimicrobial effect and biofilm inhibition towards H. pylori. Additionally, these nanoparticles did not interfere with human fibroblast viability and proliferation.
Driven by the need to find alternatives to control H. pylori infections, this work describes the development of chitosan-PMLA nanoparticulate systems as carriers for antimicrobial glycolipid. By using a simple ionic gelation method stable nanoparticle was obtained showing an encapsulation efficiency of 73.1 +/- 1.3% and an average size of 217.0 +/- 15.6 nm for rhamnolipids chitosan-PMLA nanoparticles (RL-CS-NPs). Glycolipid incorporation and particle size were correspondingly corroborated by FT-IR and TEM analysis. Rhamnolipids chitosan nanoparticles (RL-CS-NPs) presented the highest antimicrobial effect towards H. pylori (ATCC 26695) exhibiting a minimal inhibitory concentration of 132 mu g/mL and a biofilm inhibition ability of 99%. Additionally, RL-CS-NPs did not interfere with human fibroblasts viability and proliferation under the tested conditions. The results revealed that the RL-CS-NPs were able to inhibit bacterial growth showing adequate cytocompatibility and might become, after additional studies, a valuable approach to fight H. pylori biofilm related-infections.
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