期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 23, 期 6, 页码 584-595出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2020.1821669
关键词
Decursin; cervical cancer; proliferation; apoptosis
资金
- Sichuan provincial Health Commission [19PJ298, 19PJ154]
- Basic Research Programs of Science and Technology Commission Foundation of Sichuan Province [2020YJ0442]
- Technology and Human resources' Bureau of Luzhou [[2017] 241.15, 2018LZXNYD-PT03]
- Youth Funding Program of Southwest Medical University [2019ZQN043]
The study found that decursin can induce apoptosis, inhibit cell proliferation and migration in HeLa cells, and also inhibit tumor growth in vivo, possibly through the regulation of Akt activation. These findings may have implications for novel therapeutic strategies for cervical cancer.
Decursin, a coumarin compound isolated from Angelica gigas has been shown to possess multiple anti-tumor activities. But it's still little known about the effects associated with cervical cancer. To explore the anti-tumor role of decursin and gain insights into its underlying mechanisms, we analyzed proliferation in parallel with apoptosis and migration in HeLa cells. Our findings implied that decursin can provoke apoptosis, and inhibit cell proliferation, migration in HeLa cells. More importantly, decursin also inhibited the tumor growth in vivo. The mechanisms may be associated with the regulation of Akt activation, with implications for novel therapeutic strategies on cervical cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据