Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling

Decursin, a coumarin compound isolated from Angelica gigas has been shown to possess multiple anti-tumor activities. But it's still little known about the effects associated with cervical cancer. To explore the anti-tumor role of decursin and gain insights into its underlying mechanisms, we analyzed proliferation in parallel with apoptosis and migration in HeLa cells. Our findings implied that decursin can provoke apoptosis, and inhibit cell proliferation, migration in HeLa cells. More importantly, decursin also inhibited the tumor growth in vivo. The mechanisms may be associated with the regulation of Akt activation, with implications for novel therapeutic strategies on cervical cancer.

Automated summary

The study found that decursin can induce apoptosis, inhibit cell proliferation and migration in HeLa cells, and also inhibit tumor growth in vivo, possibly through the regulation of Akt activation. These findings may have implications for novel therapeutic strategies for cervical cancer.